ccrc-research | College of Dentistry and Dental Clinics

CCRP Research

Current Studies
Study	Objective	Type	Status
Data and Specimen Biorepository	The Biorepository combines the usage of dental and medical clinical information with a biological specimen DNA bank for researchers to use at the UI College of Dentistry & Dental Clinics. Patients and visitors at the University of Iowa College of Dentistry & Dental Clinics, the UI Center for Disabilities and Development, the UI Hospitals and Clinics Department of Otolaryngology and staff will be asked to participate and give consent for their clinical information and biological specimen to be collected for undefined future research purposes that will be shared, used again, or stored for future dental research purposes. Researchers can utilize the repository to study any type of health condition or disease. To collect biological specimens for undefined future research purposes that will be share, used again, or stored for future dental research purposes. Researchers can utilize the repository to study any type of health condition or disease.	Various Studies	Currently recruiting
Genetics’ Role in the Growth of the Craniofacial Complex	To identify how different facial types develop and how genes modify facial growth and teeth development in order to find a way to improve orthodontic and surgical treatment.	Craniofacial Studies	Recruitment by referral only
Oral Health Intervention for Persons with Dementia	Aim 1. Develop a functionally-tailored, modular oral care intervention for community-dwelling PWD and their caregivers. Aim 2. Conduct a 4-week study of the proposed intervention among 8 pairs of community-dwelling PWD and their caregivers, evaluating the feasibility of the proposed intervention.	Preventative and Community Health	Currently recruiting
Oral Health Needs In Older Adults With Advanced Health Conditions	The purpose of this research study is to understand the self-perceived oral health needs of older adults with advanced health conditions and barriers for accessing the needed oral care.	Preventative and Community Health	Recruitment by referral only

Completed Studies
Study	Objective	Type	Status
Simvastatin Implant Study	Determined the anti-inflammatory effect of Simvastatin when applied topically around implants with inflamed gums.	Implant Studies	Closed to recruitment
AlloDerm	A study on soft tissue grafting around implants. The purpose of this research study is to determine whether you will have a better outcome with a gum graft harvested from the roof of your mouth or a human tissue graft and how you perceive both discomfort and the esthetics of the graft during the healing period.	Implant Studies	Complete
Atlantis1	A two-arm, parallel group, randomized controlled clinical trial on adult human subjects receiving divergent or concave Atlantis™ abutments to assess peri-implant mucosa changes from prosthesis delivery to 1 year. (Primary) Compare the influence of experimental concavities in the subgingival transition zone of Atlantis™ abutments on peri-implant mucosal dynamics from final restoration delivery to one year, as compared to current Atlantis™ abutments with linear divergent transition profiles. (Secondary) Quantify the horizontal soft tissue thickness changes around concave and divergent abutment transition profiles from final restoration delivery to one year. (Secondary) Evaluate changes in peri-implant health indicators, such as Gingival Index (GI), Probing Pocket Depth (PPD), and Bleeding on Probing (BOP).	Implant Studies	Complete
Laser-Lok	A dental implant research study to compare two different implant abutment designs, micro grooved or machined, in order to determine if these texture differences have any impact on the healing of your jaw bone and gums after implant surgery.	Implant Studies	Complete
PLUS1	A randomized clinical trial assessing implant stability, marginal bone levels, and long-term implant survival between the Astra Tech OsseoSpeed TX and OsseoSpeed Plus implant systems.	Implant Studies	Complete
PROOF	A randomized clinical trial comparing the buccal soft tissue changes and marginal bone levels occurring around single-tooth implants in the maxilla using three different implant-abutment interface designs.	Implant Studies	Complete
SCOOP	A randomized clinical trial comparing marginal bone level alterations between 6mm and 11 mm Astra Tech OsseoSpeed implants in posterior jaws.	Implant Studies	Complete
3M	A partially randomized study to evaluate the demineralization and remineralization effects of 2 experimental fluoride containing dentifrices on enamel and root surface lesions relative to a control dentifrice.	Restorative Studies	Complete
ADA Chewing Gum Study	The purpose of this research study is to determine if there is any difference in salivary flow rates and plaque pH changes as a result of chewing three different sugar free chewing gums. Subjects will use the three test chewing gums at approximately the same time each day.	Preventative Studies	Complete
AST1	A randomized clinical trial examining changes in implant stability upon three different loading regimens during the first 16 weeks following implant placement.	Implant Studies	Complete
Bond Force	A randomized clinical trial to determine and compare the clinical effectiveness and durability of two commercially available adhesive/resin-based restorative systems placed in non-carious class V lesions.	Restorative Studies	Complete
IVS2	A research study to evaluate the perceived incidence of post-operative sensitivity when a full coverage all ceramic crown is fabricated in the posterior part of the mouth.	Restorative Studies	Complete
IVS3	A clinical trial to evaluate the esthetic and functional outcomes of anterior restorations done with the new Ivoclar composite system.	Restorative Studies	Complete
PGW11	A partially randomized study to evaluate the demineralization and remineralization effects of three experimental fluoride containing dentifrices on enamel and root surface lesions relative to a positive control dentifrice.	Restorative Studies	Complete
PGW12	To evaluate the demineralization and remineralization effects of three experimental fluorides containing dentifrices on enamel and root surface lesions relative to a positive control dentifrice.	Preventative Studies	Complete
Posterior Jaw Study	A randomized clinical trial to longitudinally evaluate changes in bone stiffness around dental implants placed in the posterior maxilla.	Implant Studies	Complete
Short Implant Study	This study aimed to determine the effect of obesity in type II diabetics on bone forming cells in healthy non-obese and obese type II diabetic individuals. Subjects had two ‘short-implants’ surgically placed and systemically removed and replaced with functional implants over the course of a week.	Implant Studies	Complete
TMD	A randomized study to assess the feasibility of conducting a full-scale randomized clinical trial to evaluate the effectiveness of the chiropractic Activator protocol for patients with chronic myofascial TMD.	Craniofacial Studies	Complete
TvZ Cytokine Study	A comparative study to evaluate the pro-inflammatory levels of key cytokines around implants restored with both titanium and zirconium abutments.	NA	Complete

Ongoing Studies
Study	Objective	Type	Status
Caudry	Esthetic evaluation and clinical efficacy of two piece 3 mm implants in areas of limited space	Implant Studies	Closed to Recruitment
HK1	A randomized clinical trial to evaluate esthetic and functional outcomes of anterior teeth restored with Heraeus Kulzer Diamond compared to a similar market leader composite.	Restorative Studies	Closed to recruitment
Obesity and Periodontal Inflammation	A cross-sectional study to evaluate obesity as a potential risk factor for inflammation in peri-implant tissues.	Periodontal Studies	Closed to recruitment
Osteogenics1	The purpose of this study is to clinically and radiographically assess whether the use of a ridge preservation technique significantly minimizes alveolar ridge resorption following tooth extraction.	Periodontal Studies	Closed to Recruitment
Salivary Lipids	The purpose of this research is to determine if there are any differences in lipid content and composition in saliva from people with healthy gums compared to people with gum disease. After giving informed consent, subjects would provide their age, undergo an oral examination by a dentist and spit into a tube for 15 minutes. The entire process would take about 40 minutes. Compensation is available.	Preventative Studies	Closed to recruitment